Renée Pilar Estevez was born in New York City on April 2, 1967. She is the youngest child and only daughter of Janet Sheen (née Templeton), an artist, and Martin Sheen, an actor. Her three older brothers - Emilio Estevez (b. 1962), Ramon Estevez (b. 1963), and Charlie Sheen (b. 1965) - also act.
Renée's first acting role came about in 1986, starring in an episode of CBS Schoolbreak Special (1984). Her best-known movie is probably the cult favorite Heathers (1989), in which she played the geeky Betty Finn. Renée had an uncredited appearance in the director's cut of Zwei stahlharte Profis (1987), as well as roles in two late '80s slasher films - final girl Molly in Das Camp des Grauens 2 (1988) and first victim Linda in Bloodnight (1989).
Renée Estevez has guest-starred in multiple TV shows, including Unser lautes Heim (1985), Macgyver (1985), Junge Schicksale (1972), Foxy Fantasies (1992), J.A.G. - Im Auftrag der Ehre (1995), and Lady Cops - Knallhart weiblich (2001). She appeared in a regular guest-starring role on The West Wing: Im Zentrum der Macht (1999) as Nancy, an assistant in the Oval Office of President Josiah Bartlet (who is played by her father Martin).
As of 2015, Renée's final on-screen appearance is Dein Weg (2010), which was directed and written by her brother Emilio, and co-starred Emilio and their father, Martin. She also wrote a few episodes of her brother Charlie's show Anger Management (2012).
Renée has been married to Jason Thomas Federico, a chef and golfer, since October 11, 1997. She met him at the California Culinary Academy where she studied pastry and baking science.